Protein Modeling C

[pikachu4919]

Protein Modeling C: Students will use computer visualization and online resources to construct physical models of the CRISPR Cas9 protein that is being engineered to edit plant and animal cell genomes, and answer a series of questions about the chemistry of protein folding and the interaction of structure and function for model proteins.

Protein Modeling Wiki

Protein Modeling Test Exchange

http://cbm.msoe.edu/scienceOlympiad/

Official Protein Modeling Event Facebook Page (many photos of models from nationals are posted here)

Past Threads:
2011 (Pluripotent Stem Cells)
2012 (Apoptosis)
2015 (Human Genome Editing)
2016 (Dopamine and Serotonin Synthesis)
2019 (Anti-CRISPR)
2020 (Cas9 Base Editing)

Past Question Marathons: 2015, 2019, 2020

[Mr.Epithelium]

Super excited to pull last year's prebuild out of the box again and not do anything to it

[promotions]

Hey all,

I'm competing in Protein Modeling in Southern California. I just saw an announcement on the SoCal Scilympiad website that that "[t]he three papers that competitors need to review for Regional and State competitions have been uploaded and are linked in the Events and Modifications document." The three papers are the base editing paper from last year and two other papers, which are here and here. I assume information on these papers will be tested on in the Regional and State tournaments. Has anyone else seen these papers on other tournament websites? Thanks!

[bearasauras]

Yah, these three papers were sent to the State Directors last week with the following message:
[These are] the 3 papers that each team needs to read and will use during the event for both Regionals and State tournaments. These papers are normally distributed when MSOE sends Pre-Build materials to teams; however, this season we are asking tournaments to either post them for download on their tournament website or send them to their teams directly.

[Anomaly]

Yah, these three papers were sent to the State Directors last week with the following message:
[These are] the 3 papers that each team needs to read and will use during the event for both Regionals and State tournaments. These papers are normally distributed when MSOE sends Pre-Build materials to teams; however, this season we are asking tournaments to either post them for download on their tournament website or send them to their teams directly.

Is this just for certain states or all of them?

[promotions]

Yah, these three papers were sent to the State Directors last week with the following message:
[These are] the 3 papers that each team needs to read and will use during the event for both Regionals and State tournaments. These papers are normally distributed when MSOE sends Pre-Build materials to teams; however, this season we are asking tournaments to either post them for download on their tournament website or send them to their teams directly.

Is this just for certain states or all of them?

The same papers are posted on the Missouri SO website stating that "The attached documents should be downloaded and reviewed by all teams before the regional and state tournaments." Check with your state director, but I definitely think it's likely that it's going to be required by most (if not all) states.

[EwwPhysics]

Does anyone have any tips for analyzing interactions in jmol? I often see questions about interactions between residues or ligand/protein interactions, but I'm not exactly sure how to approach them. I usually just go with the closest residue, or a nearby one that has properties that would make it likely to interact with the other thing (eg. if it's asking for something that interacts with a DNA molecule I would look for basic/positively charged amino acids). However, this method is pretty unreliable and I get these questions wrong more often than not.
Is there an easy way to identify interactions that I'm overlooking? Thanks in advance

[sciolyperson1]

Hi all!

We're running Protein Modeling for this month's SMEC! To learn more, head over to our forums thread and register at the google form here!